Common Name(s): Acetyl arginine,acetyl arginine, signal peptide,anti-aging bioactive
CAS Number: N/a
DESCRIPTION
What It Does: Stimulates collagen i, iii, iv synthesis and inhibits mmp-1 collagen degradation โ providing clinically measurable wrinkle reduction and skin firmness at ppm concentrations.
Why It's Used: Precision peptide pharmacology: the defined sequence targets specific receptors (tgf-ฮฒ, egf, integrin, achr) with quantifiable binding kinetics enabling mechanism-based efficacy claims.
How It Works: Peptide-receptor binding โ kinase cascade (map kinase, smad, or pi3k-akt) โ col1a1/col3a1 upregulation and mmp-1/mmp-3 downregulation. spps synthesis provides >98% sequence purity for reproducible receptor binding.
Typically Found In: Anti-aging serums,peptide actives
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Peptide source is cosmetically significant: chironomid freeze-tolerance proteins, silkworm fibroin peptides, and rice prolamin peptides provide the specific amino acid sequences with documented anti-aging activity from their natural structural protein functions.
Last Verified: Cosing database,acetyl arginine signal peptide review
Primary Sources: 2026-03-22