Common Name(s): Acetyl beta-alanyl tripeptide-50,acetyl beta-alanyl tripeptide-50,beta-alanine modified peptide,carnosine biosynthesis stimulating anti-aging

CAS Number: N/a

DESCRIPTION

What It Does: Stimulates collagen synthesis through peptide sequence receptor activation while simultaneously providing beta-alanine for carnosine biosynthesis — dual anti-aging mechanism from collagen upregulation and anti-glycation protection.

Why It's Used: Combining signal peptide collagen stimulation with beta-alanine carnosine precursor in one molecule provides synergistic anti-aging from two independent mechanisms — dermal matrix upregulation (collagen synthesis) and dermal matrix protection (age prevention).

How It Works: The peptide sequence activates tgf-β/smad → col1a1 upregulation. beta-alanine simultaneously enters the carnosine pathway: beta-alanine + histidine → carnosine (by carnosine synthetase) → carbonyl quenching of methylglyoxal/4-hne preventing age crosslinks on collagen. the dual mechanism addresses both collagen quantity and quality.

Typically Found In: Premium anti-aging serums

TECHNICAL DETAILS

Primary Category: Active ingredient – peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Typical Concentration Range: 1–5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Beta-alanine-containing peptides provide superior carnosine pathway stimulation versus free beta-alanine — the peptide scaffold improves sc penetration delivering beta-alanine deeper into the dermis where carnosine synthetase is concentrated in fibroblasts.

Last Verified: Cosing database,acetyl beta-alanyl tripeptide-50 beta-alanine peptide anti-aging review

Primary Sources: 2026-03-22