Common Name(s): Calmosensine,neuro-calm peptide

CAS Number: N/a

DESCRIPTION

What It Does: Inhibits substance p-mediated neurogenic inflammation, reducing stress-related skin sensitivity and redness.

Why It's Used: Used in sensitive skin products targeting neurogenic inflammation – the link between psychological stress and skin reactivity not addressed by standard anti-inflammatory ingredients.

How It Works: Competes with substance p (sp) for nk1 receptor binding. prevents sp-mediated mast cell degranulation and inflammatory cytokine release that drives neurogenic skin inflammation, flushing, and hypersensitivity.

Typically Found In: Sensitive skin serums,stress-protection formulations,anti-redness products

TECHNICAL DETAILS

Primary Category: Active ingredient – defensin stimulating peptide

Secondary Functions: Neurogenic inflammation reduction,stress protection,anti-redness

Application Areas:

Typical Concentration Range: 50–500 ppm

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes

Source Notes: Synthetically produced. encapsulation may improve delivery to neuromuscular junction.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,moisturizers

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Substance p is the primary neurotransmitter of neurogenic inflammation in skin – released by sensory neurons in response to stress, heat, capsaicin. its nk1 receptor binding drives mast cell activation and the stress-skin connection, making calmosensine uniquely relevant for modern stress-driven skin conditions.

Last Verified: Cosing database,lintner calmosensine technical data

Primary Sources: 2026-03-12