Common Name(s): Acetyl hexapeptide-1,hexapeptide signal peptide,anti-aging active
CAS Number: N/a
DESCRIPTION
What It Does: Stimulates collagen i, iii, and iv synthesis, inhibits collagen-degrading mmp-1 and mmp-3, and promotes dermal matrix density for firmer, more elastic skin with reduced wrinkle depth.
Why It's Used: Provides precision receptor targeting (tgf-ฮฒ, egf, or integrin receptors) that broad-spectrum botanicals cannot replicate, with clinical-grade purity and quantified in-vitro efficacy at 1โ5000 ppm.
How It Works: The hexapeptide amino acid sequence binds specific receptors activating map kinase or smad signalling cascades, upregulating col1a1, col3a1, and fibronectin genes while downregulating mmp-1.
Typically Found In: Anti-aging serums,collagen actives
TECHNICAL DETAILS
Primary Category: Active ingredient โ signal peptide
Secondary Functions: Collagen stimulation,skin firming,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide
Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)
SCIENTIFIC NOTE
Synthetic hexapeptide sequences are designed from naturally occurring signal protein domains (collagen propeptides, growth factor active sites) and synthesised by solid-phase peptide synthesis to >98% purity.
Last Verified: Cosing database,acetyl hexapeptide-1 signal peptide review
Primary Sources: 2026-03-12