Common Name(s): Adenine,adenine,purine base,dna repair skin renewal active

CAS Number: N/a

DESCRIPTION

What It Does: Supports keratinocyte dna repair by augmenting the purine nucleotide pool for nucleotide excision repair (ner) of uv-induced cpd lesions, contributes to cellular energy as an atp biosynthesis building block, and provides mild anti-proliferative regulatory activity through adenosine receptor modulation.

Why It's Used: Uv-stressed skin cells face a transiently depleted purine pool as ner consumes nucleotides for dna synthesis — adenine supplementation supports the repair process by maintaining purine availability during the repair window.

How It Works: Adenine enters the purine salvage pathway: adenine + prpp → amp → adp → atp (adenylate kinase). atp supports ner: dna damage recognition (xpc), helicase unwinding (tfiih), endonuclease incision (xpf/xpg), resynthesis polymerisation, and ligation each consume atp. adenine also serves as a nitrogen source for all purine nucleotides (atp, gtp, ctp precursors).

Typically Found In: Anti-aging,dna repair support,uv recovery

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.001%–0.5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Purine base complementarity with skin: adenine is the natural degradation product of the skin's endogenous purine turnover — the gras-level safety of this universal cellular metabolite directly supports cosmetic use.

Last Verified: Cosing database,adenine purine base dna repair skin renewal review

Primary Sources: 2026-03-22