Common Name(s): Alanine/histidine/lysine polypeptide copper hcl
DESCRIPTION
What It Does: Supports anti-aging skin structure by stimulating collagen and elastin synthesis and modulating skin matrix metalloproteinase activity.
Why It's Used: Peptide sequences mimic endogenous skin communication molecules, triggering cellular responses that decline with age — restoring youthful skin structure.
How It Works: Specific amino acid sequences bind to cell surface receptors or penetrate to fibroblasts where they activate growth factor pathways, tgf-β signaling, or mmp-inhibiting mechanisms, stimulating ecm remodeling.
Typically Found In: Anti-aging serums,ampoules,eye creams,firming moisturizers
TECHNICAL DETAILS
Primary Category: Bioactive peptides
Secondary Functions: Anti-aging,skin-conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001–2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetic or recombinant peptide; no animal-derived material.
SKIN COMPATIBILITY
Irritancy Rating: 1
Comedogenicity Rating: 0
Sensitivity Concerns: Low sensitization potential at recommended use concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.
Works Well With: Retinol,vitamin c,hyaluronic acid,niacinamide
Avoid Combining With: Proteolytic enzymes (papain, bromelain); extreme ph
SCIENTIFIC NOTE
Cosmetic peptides are typically 2–10 amino acids, short enough for transdermal penetration but specific enough for receptor binding. their bioactivity depends on sequence (primary structure), lipophilization (e.g., palmitoyl modification increases skin penetration 10-fold), and resistance to skin proteases — often achieved through d-amino acid substitution or terminal modifications.
Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; j pept sci peptide cosmetic reviews; j cosmet dermatol clinical studies
Primary Sources: 2025-01-15