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Common Name(s): Allantoin glycyrrhetinic acid,allantoin healing active,keratolytic soothing agent

CAS Number: N/a

DESCRIPTION

What It Does: Soothes irritated and reactive skin, promotes healthy cell proliferation and tissue repair, provides gentle keratolytic action for smoother skin texture, and qualifies as an fda skin protectant active.

Why It's Used: One of the most well-tolerated multi-functional actives in cosmetics โ€” fda otc skin protectant, wound healing promoter, and keratolytic, with a 50+ year safety and efficacy record across all skin types.

How It Works: Allantoin complexes with denatured proteins in the sc increasing water binding and softening thickened skin. it stimulates fibroblast proliferation through tgf-ฮฒ1 pathway activation for wound healing, and its anti-irritant mechanism involves free radical scavenging and inflammatory signalling modulation.

Typically Found In: Soothing skin care,after-sun,wound healing

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ soothing / anti-inflammatory

Secondary Functions: Redness reduction,anti-inflammatory,calming

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%โ€“2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes โ€“ particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Allantoin holds fda otc skin protectant status and is listed in the cir (cosmetic ingredient review) as safe and effective at 0.1โ€“2% โ€” one of the most regulatory-validated multi-functional cosmetic actives.

Last Verified: Cosing database,allantoin glycyrrhetinic acid allantoin healing review

Primary Sources: 2026-03-12