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Common Name(s): Aloesin,aloesin,aloe vera chromone glycoside,tyrosinase inhibitor brightening

CAS Number: N/a

DESCRIPTION

What It Does: Provides non-competitive tyrosinase inhibition for skin brightening โ€” uniquely additive with competitive tyrosinase inhibitors (kojic acid, arbutin, vitamin c) allowing combination formulas to achieve greater brightening than any single inhibitor alone.

Why It's Used: Aloesin's non-competitive mechanism fills the inhibition gap that competitive inhibitors cannot โ€” by binding outside the active site, aloesin inhibits enzyme activity even when substrate occupies the active site, providing brightening under conditions where competitive inhibitors fail.

How It Works: Aloesin binds the allosteric regulatory site of tyrosinase (not the cuยฒโบ active site) โ€” non-competitive inhibition: aloesin reduces vmax without changing km. combined with competitive inhibitors (kojic acid, ic50 10 ฮผm active site; aloesin ic50 ~50 ฮผm allosteric): combined inhibition is multiplicative not additive, achieving 90%+ inhibition at concentrations where each alone achieves 50%.

Typically Found In: Brightening,anti-aging,sensitive skin

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%โ€“2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Aloesin c-glucoside stability: the carbon-carbon glycosidic bond (c-glucoside) is uniquely resistant to glycosidase hydrolysis versus o-glucoside forms โ€” aloesin maintains full activity throughout product shelf life without enzymatic degradation.

Last Verified: Cosing database,aloesin aloe chromone non-competitive tyrosinase brightening review

Primary Sources: 2026-03-22