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Common Name(s): Aminopropyl kojyl phosphate,aminopropyl kojyl phosphate,kojic acid derivative brightening,tyrosinase cuยฒโบ chelator stable

CAS Number: N/a

DESCRIPTION

What It Does: Inhibits tyrosinase through the kojic acid moiety's cuยฒโบ chelation at the enzyme active site โ€” providing skin brightening with improved formulation stability versus free kojic acid which discolours products rapidly.

Why It's Used: Free kojic acid's iron-catalysed auto-oxidation causes rapid product yellowing โ€” the aminopropyl kojyl phosphate modification blocks the primary oxidation pathway providing 5-10ร— improved colour stability while retaining full tyrosinase inhibitory activity.

How It Works: Aminopropyl kojyl phosphate: the phosphate group blocks the c4-oh auto-oxidation initiation; the aminopropyl chain provides solubility and membrane affinity for sc penetration. skin phosphatases slowly hydrolyse the phosphate releasing free kojic acid intracellularly for cuยฒโบ chelation at the tyrosinase active site (ic50 ~10 ฮผm).

Typically Found In: Brightening,anti-melanogenic

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%โ€“2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Kojic acid derivative stability comparison: kojyl phosphate > kojic acid dipalmitate > free kojic acid in aqueous formulations โ€” the phosphate ester provides the best aqueous-phase stability while retaining sufficient water solubility for serum and toner incorporation.

Last Verified: 2026-03-22

Primary Sources: Cosing database,aminopropyl kojyl phosphate kojic acid derivative brightening review