Common Name(s): Aminosuberic acid,aminosuberic acid,non-natural amino acid,peptide stability enhancer
CAS Number: N/a
DESCRIPTION
What It Does: Provides a non-natural amino acid scaffold for peptide sequence modification that sterically resists skin protease cleavage, extending peptide half-life in formulation and on skin.
Why It's Used: Aminosuberic acid is selected for peptide engineering โ incorporating the diaminosuberic acid residue at protease-sensitive sites of cosmetic signal peptides provides proteolytic resistance without disrupting the receptor-binding pharmacophore, extending in-vivo peptide activity duration.
How It Works: Aminosuberic acid incorporation โ peptide tertiary structure constraint โ steric hindrance of protease active site access โ reduced degradation rate โ extended peptide receptor activity on skin.
Typically Found In: Anti-aging,peptide formulas
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Aminosuberic acid-modified peptides typically show 3โ5ร longer skin surface half-life than proteinogenic equivalents โ the non-natural residue preventing trypsin and chymotrypsin cleavage.
Last Verified: 2026-03-22
Primary Sources: Cosing database,aminosuberic acid peptide stability enhancer review