Common Name(s): Argireline,acetyl hexapeptide-8,snap-25 fragment
CAS Number: 616204-22-9
DESCRIPTION
What It Does: Provides snare complex competitive inhibition for expression line and dynamic wrinkle reduction.
Why It's Used: The original and most studied neurocosmetic peptide โ argireline pioneered the snare inhibitor class with the most clinical study data of any expression line reducing peptide.
How It Works: 6-residue n-terminal snap-25 mimetic competitively inhibits snare complex assembly. reduced snare complex formation โ reduced vesicle fusion โ reduced acetylcholine exocytosis at neuromuscular junction โ reduced muscle contraction force โ reduced expression line depth.
Typically Found In: Expression line products,anti-wrinkle serums,neurocosmetic products
TECHNICAL DETAILS
Primary Category: Active ingredient โ signal peptide
Secondary Functions: Collagen stimulation,skin firming,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.0001%โ0.1%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide
Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)
SCIENTIFIC NOTE
Argireline's snare mechanism was validated by blanes-mira et al. (2002) in the first published characterisation of a cosmetic snare inhibitor, demonstrating acetyl hexapeptide-3 reduced acetylcholine release at neuromuscular junctions in cell models by ~21% at 10ฮผg/ml โ establishing the pharmacological basis for all subsequent neurocosmetic snare peptides.
Last Verified: 2026-03-12
Primary Sources: Cosing database,blanes-mira et al. argireline snare study