Common Name(s): Aa2g,2-o-alpha-d-glucopyranosyl-l-ascorbic acid

CAS Number: 129499-78-1

DESCRIPTION

What It Does: Provides stable gradual-release vitamin c activity for brightening and antioxidant protection.

Why It's Used: Most formulation-stable vitamin c derivative — ascorbyl glucoside remains stable in aqueous formulations where pure ascorbic acid oxidises within days, providing sustained vitamin c delivery over weeks of shelf life.

How It Works: Alpha-glucoside bond resists oxidation until cleaved by skin alpha-glucosidase enzymes. releases free l-ascorbic acid in viable epidermis. released ascorbic acid inhibits tyrosinase, stimulates collagen synthesis, and provides antioxidant activity. glucose group provides enhanced water solubility vs ascorbic acid.

Typically Found In: Stable vitamin c serums,brightening products,anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient – stable vitamin c glucoside

Secondary Functions: Tyrosinase inhibitor,collagen cofactor

Application Areas:

Typical Concentration Range: 1%–5%

SOURCING & ETHICS

Vegan Status: Yes – enzymatic synthesis from ascorbic acid and glucose

Halal Status: Yes

Source Notes: Synthetically produced vitamin c derivative.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Tocopherol,ferulic acid,niacinamide,spf

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Ascorbyl glucoside's stability advantage (18+ months in aqueous formulation vs days for ascorbic acid) arises from the glucose group's steric protection of ascorbic acid's c2 enediol that is the primary oxidation site. glucosidase cleavage in skin removes this protection in situ, releasing active ascorbic acid only where enzymatic activity exists — providing both formulation stability and bioactivation where needed.

Last Verified: ##########

Primary Sources: Cosing database,yamamoto et al. ascorbyl glucoside stability study