Common Name(s): Aureobasidium pullulans ferment extract,postbiotic ferment,biotransformed botanical active filtrate
CAS Number: N/a
DESCRIPTION
What It Does: Supports skin microbiome ph balance through organic acid production, delivers biotransformed polyphenols with 10-50x improved sc penetration, and provides anti-inflammatory trained immunity via tlr2 activation from bacterial cell wall fragments.
Why It's Used: Postbiotic filtrates deliver live-probiotic-equivalent microbiome benefits in a conventional cosmetically stable format requiring no cold chain and compatible with standard preservative systems.
How It Works: Aureobasidium fermentation beta-glucosidase cleaves botanical polyphenol glycosides generating aglycone forms with lower mw and higher logp for improved transdermal flux. organic acid production lowers filtrate ph to 4.5-5.5 reinforcing skin acid mantle. lipoteichoic acid (lta) cell wall fragments activate tlr2/tlr6 driving anti-inflammatory il-10 production and trained tolerogenic immunity.
Typically Found In: Microbiome skin care,postbiotic,anti-inflammatory
TECHNICAL DETAILS
Primary Category: Active ingredient โ skin microbiome support
Secondary Functions: Microbiome balance,prebiotic effect
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ15%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Fermentation-derived or plant-extracted.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; beneficial for sensitive skin.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,niacinamide,soothing actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Tlr2 trained immunity duration: sustained tlr2 stimulation from postbiotic application induces epigenetic modification of keratinocyte and langerhans cell phenotype providing anti-inflammatory benefits that outlast the product residence time.
Last Verified: 2026-03-12
Primary Sources: Cosing database,aureobasidium postbiotic biotransformation review