Common Name(s): Azulene,chamomile sesquiterpene,anti-inflammatory blue chromophore

CAS Number: N/a

DESCRIPTION

What It Does: Reduces skin inflammation and redness through nf-kb and cox-2 inhibition, provides potent antioxidant activity from the electron-rich azulene aromatic system, and delivers the visible confirmation of authentic german chamomile activity through its characteristic intense blue colour.

Why It's Used: The visible blue colour of azulene provides formulation differentiation and consumer assurance of authentic chamomile chemistry — a rare case where an anti-inflammatory active provides its own visible quality indicator.

How It Works: Azulene's non-benzenoid 5-7 fused ring system has higher electron density than benzene rings, providing excellent single-electron donation to free radicals. nf-kb inhibition occurs through azulene's electrophilic interaction with ikb kinase cysteine residues; cox-2 inhibition through intercalation at the enzyme active site hydrophobic channel.

Typically Found In: Anti-inflammatory soothing,chamomile products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Azulene is a thermal rearrangement product of matricine and chamazulene precursors during steam distillation of chamomile — not present in the fresh plant but formed during essential oil production. the intensity of blue colour indicates distillation temperature and duration, providing a quality indicator for chamomile oil processing conditions.

Last Verified: 2026-03-12

Primary Sources: Cosing database,azulene chamomile anti-inflammatory blue sesquiterpene review