Common Name(s): Baicalein,baicalein,scutellaria flavone anti-inflammatory,5-lox+cox inhibitor
CAS Number: N/a
DESCRIPTION
What It Does: Provides comprehensive anti-inflammatory coverage through simultaneous 5-lox inhibition (blocking ltb4 leukotrienes) and cox-1/2 inhibition (blocking prostaglandins), antioxidant radical scavenging, and anti-fibrosis activity preventing excess collagen scarring in wound healing.
Why It's Used: Baicalein's dual lox+cox inhibition provides broader anti-inflammatory coverage than either pathway alone โ the leukotriene and prostaglandin pathways are complementary inflammatory cascades, and blocking both provides superior anti-inflammatory benefit than selective inhibition.
How It Works: Baicalein catechol b-ring: c6-oh and c7-oh form chelate with feยฒโบ in 5-lox active site โ competitive inhibition ic50 ~0.6 ฮผm. simultaneously, the flavone c=o positions the molecule for cox-1/2 active site binding โ ic50 ~2 ฮผm prostaglandin inhibition. anti-fibrosis: baicalein inhibits tgf-ฮฒ1-smad3 pathway โ reduced collagen type i overexpression in fibroblasts โ anti-scar activity.
Typically Found In: Anti-inflammatory,anti-aging,wound healing
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Baicalein vs baicalin (baicalin = baicalein + glucuronide): baicalin is more water-soluble but requires beta-glucuronidase for activation in skin; baicalein provides immediate activity but lower aqueous solubility. formulation selection depends on delivery format and target application.
Last Verified: 2026-03-22
Primary Sources: Cosing database,baicalein 5-lox cox anti-inflammatory scutellaria review