Common Name(s): Scutellaria baicalensis extract active,chinese skullcap flavonoid
CAS Number: 21967-41-9
DESCRIPTION
What It Does: Provides potent nf-kb anti-inflammatory and antioxidant activity from chinese skullcap's primary flavonoid.
Why It's Used: Premium anti-aging anti-inflammatory flavonoid from tcm with potent nf-kb inhibition and sirt1 anti-aging mechanism.
How It Works: Inhibits ikk-beta in the nf-kb pathway preventing iฮบb phosphorylation and nf-kb nuclear translocation. activates sirt1 for anti-aging gene regulation. inhibits mmp-1 and mmp-3 protecting collagen. antioxidant via flavone 5,6,7-trihydroxy radical scavenging.
Typically Found In: Tcm anti-aging serums,anti-inflammatory products,premium anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Nf-kb inhibition,sirt1 activation,mmp inhibition
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ2%
SOURCING & ETHICS
Vegan Status: Yes โ from scutellaria baicalensis roots
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Baicalin's sirt1 activation combined with nf-kb inhibition provides a unique dual anti-aging mechanism: simultaneously reducing inflammatory aging (nf-kb pathway) and activating the caloric restriction anti-aging pathway (sirt1). this combination distinguishes baicalin from resveratrol (sirt1 only) and most anti-inflammatories (nf-kb only).
Last Verified: ##########
Primary Sources: Cosing database,li et al. baicalin anti-aging review