Common Name(s): Bryonolic acid,bryonolic acid,cucurbitane triterpenoid,anti-inflammatory terpenoid

CAS Number: N/a

DESCRIPTION

What It Does: Provides cucurbitane triterpenoid anti-inflammatory activity via nf-kb and mapk inhibition for skin anti-redness, anti-acne, and soothing applications.

Why It's Used: Bryonolic acid is selected for the cucurbitane scaffold's potent multi-pathway anti-inflammatory pharmacology — the c9,10-cyclopropane triterpenoid architecture provides a distinct nf-kb/mapk inhibition mechanism complementing the more common lupane and ursane-class triterpenoids.

How It Works: Bryonolic acid cucurbitane: nf-kb iκb kinase inhibition → reduced tnf-α/il-6; mapk jnk/erk inhibition → reduced keratinocyte inflammatory response; cox-2 inhibition → reduced prostaglandin synthesis.

Typically Found In: Anti-inflammatory,anti-acne,sensitive skin

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.05%–2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Bryonolic acid is particularly effective in combination with other anti-inflammatory actives — the cucurbitane mechanism is complementary to both polyphenol nf-kb inhibitors and terpenoid cox inhibitors.

Last Verified: 2026-03-22

Primary Sources: Cosing database,bryonolic acid cucurbitane triterpenoid anti-inflammatory review