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Common Name(s): Cannabinol,cannabinol,non-psychoactive cannabinoid,cb1/cb2 anti-inflammatory skin active

CAS Number: N/a

DESCRIPTION

What It Does: Provides cb1/cb2-mediated anti-inflammatory activity reducing neurogenic inflammation and cytokine-driven skin irritation, antioxidant protection from the resorcinol's radical scavenging, and sebum regulation through cb2-mediated sebocyte receptor modulation.

Why It's Used: Non-psychoactive cannabinoids provide the endocannabinoid skin benefits without the regulatory complexity of cbd (cannabidiol) or thc โ€” cbn and cbg are not scheduled substances in most markets enabling broader formulation freedom.

How It Works: Cbn is oxidised thc with minimal cb1 activity (ec50 >1 ฮผm) but potent cb2 agonism (ec50 ~100 nm) โ€” cb2 activation on skin mast cells and macrophages inhibits tnf-ฮฑ/il-6 production. resorcinol chromophore donates h-atoms to ros for antioxidant scavenging.

Typically Found In: Anti-inflammatory,sensitive skin,anti-acne

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%โ€“1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Cannabinoid regulatory status: cbn and cbg are not scheduled under un drug conventions in most countries โ€” verify local cosmetic ingredient approval status in each target market as regulations for cannabis-derived compounds vary significantly by jurisdiction.

Last Verified: 2026-03-22

Primary Sources: Cosing database,cannabinol non-psychoactive cannabinoid anti-inflammatory review