Common Name(s): Cannabis sativa sprout,cannabis sativa sprout,non-psychoactive cannabinoid,cb1/cb2 anti-inflammatory skin active
CAS Number: N/a
DESCRIPTION
What It Does: Provides cb1/cb2-mediated anti-inflammatory activity reducing neurogenic inflammation and cytokine-driven skin irritation, antioxidant protection from the resorcinol's radical scavenging, and sebum regulation through cb2-mediated sebocyte receptor modulation.
Why It's Used: Non-psychoactive cannabinoids provide the endocannabinoid skin benefits without the regulatory complexity of cbd (cannabidiol) or thc โ cbn and cbg are not scheduled substances in most markets enabling broader formulation freedom.
How It Works: Cbg binds both cb1 (ki ~440 nm) and cb2 (ki ~337 nm) with balanced agonism โ the 'mother cannabinoid' from which thc, cbd, and cbc are biosynthesised, providing anti-inflammatory cb2 activation without cb1 psychoactivity. resorcinol chromophore donates h-atoms to ros for antioxidant scavenging.
Typically Found In: Anti-inflammatory,sensitive skin,anti-acne
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Cannabinoid regulatory status: cbn and cbg are not scheduled under un drug conventions in most countries โ verify local cosmetic ingredient approval status in each target market as regulations for cannabis-derived compounds vary significantly by jurisdiction.
Last Verified: 2026-03-22
Primary Sources: Cosing database,cannabis sativa sprout non-psychoactive cannabinoid anti-inflammatory review