Common Name(s): Cica leaf extract,gotu kola leaf extract

CAS Number: 84696-21-9

DESCRIPTION

What It Does: Provides cica-active wound healing and anti-inflammatory benefits from the leaf fraction.

Why It's Used: Cica leaf fraction for formulations standardizing to specific leaf-fraction triterpene profile distinct from whole-plant extract.

How It Works: Leaf fraction provides high madecassoside content alongside quercetin and kaempferol flavonoids. flavonoids provide additional antioxidant and anti-inflammatory activity complementary to triterpene activity.

Typically Found In: Cica serums,wound healing products,soothing formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Redness reduction,anti-inflammatory,calming

Application Areas:

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes – from centella asiatica leaves

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Centella asiatica leaf extract's higher flavonoid content vs whole-plant extract provides additional nf-kb inhibition pathway beyond the triterpene tgf-beta signaling, providing a complementary anti-inflammatory mechanism for comprehensive formulations targeting multiple inflammation pathways.

Last Verified: 2026-03-12

Primary Sources: Cosing database,bylka et al. centella review