Common Name(s): Ceramide 2,n-palmitoyldihydrosphingosine
CAS Number: 100403-19-8
DESCRIPTION
What It Does: Strengthens skin barrier and reduces inflammation in sensitive, atopic, and compromised skin.
Why It's Used: Part of comprehensive ceramide barrier repair complexes; important for formulations targeting sensitive and atopic dermatitis-prone skin.
How It Works: Dihydrosphingosine backbone provides slightly different lamellar packing geometry than sphingosine-based ceramides, filling structural positions within the lamellar body that other ceramides cannot occupy.
Typically Found In: Sensitive skin moisturizers,eczema care,barrier repair serums
TECHNICAL DETAILS
Primary Category: Active ingredient โ ceramide / barrier lipid
Secondary Functions: Anti-inflammatory,barrier support
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Synthetic production or phytoceramide analog from plant sources. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Endogenous molecule; excellent tolerability.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. natural skin component. ewg score: 1.
Works Well With: Other ceramides,cholesterol,free fatty acids,hyaluronic acid,niacinamide
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Ceramide ng and np together represent the majority of stratum corneum ceramide content. their complementary lamellar body positioning means both are required for complete barrier restoration โ formulations with both show clinically superior barrier repair vs single ceramide products.
Last Verified: 2026-03-12
Primary Sources: Cosing database,elias ceramide structure review