Common Name(s): Chelidonine,chelidonine,isoquinoline alkaloid,anti-proliferative anti-wart active
CAS Number: N/a
DESCRIPTION
What It Does: Provides anti-proliferative activity through tubulin polymerisation inhibition for anti-wart and anti-keratosis applications, antimicrobial activity from the quaternary isoquinoline nitrogen's membrane disruption, and anti-inflammatory nf-kb modulation.
Why It's Used: Chelidonine's tubulin inhibition provides a unique anti-proliferative mechanism for skin applications โ disrupting microtubule formation in abnormally proliferating cells (wart hpv-infected cells, comedones) without the keratinocyte toxicity of synthetic anti-proliferatives.
How It Works: Chelidonine's beta-methylenedioxy phenanthridine ring system intercalates with tubulin ฮฒ-subunit preventing polymerisation into microtubules โ mitotic arrest (m-phase block) in rapidly dividing cells. at low concentrations: selective cytostasis of hpv-infected (wart) cells and hyperproliferative comedone keratinocytes. topoisomerase ii inhibition provides secondary dna-repair stress in abnormal cells.
Typically Found In: Anti-wart,anti-keratosis,anti-acne
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ0.5%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Chelidonium majus latex has historic use for wart treatment across european folk medicine โ the alkaloid concentration in the fresh plant sap is high enough to cause selective cytotoxicity at the application site. cosmetic formulations use purified chelidonine at precise low concentrations for controlled anti-proliferative benefit.
Last Verified: 2026-03-22
Primary Sources: Cosing database,chelidonine isoquinoline anti-proliferative anti-wart review