Common Name(s): Chondroitin sulphate,cs-a,cs-c
CAS Number: 9007-28-7
DESCRIPTION
What It Does: Provides ha-comparable deep hydration with ecm structural support from sulfated glycosaminoglycan chemistry.
Why It's Used: Ecm-authentic glycosaminoglycan humectant providing structural ecm support alongside deep hydration in anti-aging formulations.
How It Works: Sulfated polysaccharide with negative charges from both carboxylate and sulfate groups provides water binding approaching ha's capacity. component of proteoglycans (aggrecan, versican) that structurally organize dermal ecm. also promotes collagen and ha synthesis in fibroblasts.
Typically Found In: Anti-aging serums,deep hydration products,ecm support formulations
TECHNICAL DETAILS
Primary Category: Active ingredient โ glycosaminoglycan humectant
Secondary Functions: Ecm structural support,ha-comparable hydration
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ3%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Traditional bovine (trachea) or shark cartilage source. biotechnology-derived options available. verify source for vegan/halal. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Chondroitin sulfate's sulfation pattern (cs-a = 4-o-sulfate; cs-c = 6-o-sulfate) determines its biological activity beyond simple water binding โ specific sulfation patterns are recognized by growth factor receptors and ecm organizing proteins, providing biological activity not available from non-sulfated glycosaminoglycans like ha.
Last Verified: 2026-03-12
Primary Sources: Cosing database,trowbridge & gallo cs review