Common Name(s): Cyanomethylphenyl menthane carboxamide,cyanomethylphenyl menthane carboxamide,cooling agent,non-menthol trpm8 activator
CAS Number: N/a
DESCRIPTION
What It Does: Provides intense trpm8-mediated cooling sensation at concentrations 10-100× lower than menthol — the carboxamide pharmacophore providing high receptor affinity with minimal peppermint fragrance intensity.
Why It's Used: Synthetic cooling agents provide cooling performance separated from menthol fragrance — enabling formulation of intensely cooling products for oral care and deodorants where maximum cooling with minimal menthol scent is desired.
How It Works: Cyclohexane carboxamide scaffold activates trpm8 through hydrophobic pocket binding in the s1-s4 transmembrane domain — the carboxamide c=o hydrogen bonds with tyr745 while the alkyl chain occupies the lipophilic binding pocket. higher binding affinity than menthol (ec50 0.1-1 μm vs menthol 10 μm) provides equivalent cooling at 10-100× lower concentration.
Typically Found In: Oral care,cooling cosmetics,deodorants
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%–0.1%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Ws-12 (synthetic cooling agent) is the reference for this carboxamide cooling class — 3000× more potent than menthol with essentially zero peppermint fragrance, enabling pure cooling sensation without flavour/scent implications.
Last Verified: 2026-03-22
Primary Sources: Cosing database,cyanomethylphenyl menthane carboxamide synthetic cooling trpm8 review