Common Name(s): D-nonapeptide-2,d-nonapeptide-2,d-amino acid containing peptide,protease-resistant anti-aging active
CAS Number: N/a
DESCRIPTION
What It Does: Provides sustained receptor-mediated collagen synthesis stimulation from protease-resistant d-amino acid containing sequence — the d-configuration extending skin half-life 10-100× versus equivalent l-amino acid sequences.
Why It's Used: D-amino acid substitution at protease cleavage sites eliminates the primary inactivation pathway for cosmetic peptides — natural aminopeptidases and endoproteases have strict stereochemical selectivity for l-amino acid substrates, leaving d-containing peptides intact.
How It Works: Serine proteases (scce, cathepsins) have s1 pocket geometry complementary only to l-amino acid p1 residues — d-amino acid substitution at p1 position eliminates productive enzyme-substrate complex formation providing >100-fold increased protease resistance. the d-residue maintaining receptor binding through asymmetric docking geometry.
Typically Found In: Premium anti-aging,long-duration actives
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1–5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
D-peptide receptor binding: d-amino acid substitution at non-binding-contact residues maintains receptor affinity while providing protease resistance. strategic placement of d-residues at protease-sensitive positions while maintaining l-residues at receptor contact positions provides the optimal stability-activity balance.
Last Verified: 2026-03-22
Primary Sources: Cosing database,d-nonapeptide-2 d-amino acid peptide anti-aging review