Common Name(s): Darutoside,darutoside,siegesbeckia diterpene glycoside,anti-inflammatory joint-mimetic active

CAS Number: N/a

DESCRIPTION

What It Does: Provides dual nf-kb and cox-2 inhibition for comprehensive anti-inflammatory skin and scalp care — the labdane diterpene's multiple inflammatory pathway targeting providing superior anti-inflammatory coverage from one natural compound.

Why It's Used: Darutoside's dual nf-kb + cox-2 inhibition provides complementary anti-inflammatory coverage — nf-kb blocks cytokine gene transcription (upstream) while cox-2 inhibition blocks prostaglandin synthesis (downstream), providing more complete inflammatory cascade blockade than single-pathway inhibitors.

How It Works: Darutoside diterpene skeleton: iκb kinase β inhibition via terpenoid binding → nf-κb nuclear translocation blocked → reduced tnf-α/il-1β/il-6 (upstream pathway). simultaneously: cox-2 active site competitive inhibition → reduced pge2/pgi2 → reduced vasodilation and sensitisation (downstream pathway).

Typically Found In: Anti-inflammatory,scalp care,sensitive skin

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Siegesbeckia orientalis (st. paul's wort) has documented traditional use in tcm for rheumatoid arthritis — the anti-inflammatory mechanism directly applicable to skin inflammatory conditions including eczema, scalp inflammation, and reactive skin.

Last Verified: 2026-03-22

Primary Sources: Cosing database,darutoside labdane diterpene nf-kb cox-2 anti-inflammatory review