Common Name(s): Diacetylresveratryl thioctate,diacetylresveratryl thioctate,resveratrol + lipoic acid conjugate,dual antioxidant anti-aging
CAS Number: N/a
DESCRIPTION
What It Does: Provides sirt1 sirtuin anti-aging pathway activation from the resveratrol moiety, mitochondrial antioxidant protection and nrf2 activation from alpha-lipoic acid, and oxidative stability from the diacetyl protection — triple anti-aging mechanism from one synthetic conjugate.
Why It's Used: The conjugate approach combines three clinically validated anti-aging mechanisms (sirt1, nrf2, mitochondrial antioxidant) in one stable molecule — providing synergistic anti-aging activity that no single-molecule approach can match.
How It Works: Diacetyl protection blocks resveratrol's auto-oxidation while tissue esterases release free resveratrol + thioctic acid. resveratrol → sirt1 deacetylase activation → pgc-1α → mitochondrial biogenesis. thioctic acid → nrf2 pathway (are activation → ho-1, sod, catalase) + direct mitochondrial antioxidant (the only antioxidant active in both lipid and aqueous phases).
Typically Found In: Premium anti-aging,mitochondrial support
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Alpha-lipoic acid uniquely regenerates vitamins c and e after they scavenge radicals — the lipoic acid component in this conjugate provides the regenerative antioxidant network extending the activity of co-formulated vitamin antioxidants.
Last Verified: 2026-03-22
Primary Sources: Cosing database,diacetylresveratryl thioctate resveratrol lipoic acid dual anti-aging review