Common Name(s): Dipotassium bryonolyl succinate,dipotassium bryonolyl succinate,bryonolic acid salt,soluble anti-inflammatory triterpenoid

CAS Number: N/a

DESCRIPTION

What It Does: Provides cucurbitane triterpenoid anti-inflammatory activity via nf-kb and mapk inhibition in a water-soluble dipotassium succinate salt format for aqueous formulation.

Why It's Used: Dipotassium bryonolyl succinate is selected to deliver bryonolic acid's anti-inflammatory pharmacology in water-based formulas — the succinate ester and dipotassium salt transformation provides full aqueous solubility while the enzymatic hydrolysis at skin surface regenerates the active cucurbitane triterpenoid.

How It Works: Dipotassium bryonolyl succinate → skin succinate esterase hydrolysis → bryonolic acid → nf-kb iκb kinase inhibition → reduced il-6/tnf-α; mapk jnk inhibition → keratinocyte normalisation.

Typically Found In: Anti-inflammatory,anti-acne,sensitive skin

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.1%–3%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The succinate salt form provides ph-neutral aqueous solubility — free bryonolic acid's high lipophilicity requires >50% co-solvent for aqueous incorporation.

Last Verified: 2026-03-22

Primary Sources: Cosing database,dipotassium bryonolyl succinate cucurbitane triterpenoid review