Common Name(s): Disodium inosinate,disodium inosinate (imp),purine nucleotide,cellular energy skin active
CAS Number: N/a
DESCRIPTION
What It Does: Supports cellular energy metabolism through purine nucleotide delivery to energy-depleted skin cells, promotes cell proliferation through p2 receptor activation, and provides dna repair support from purine availability during uv-damaged cell recovery.
Why It's Used: Nucleotide topical delivery supports the energy-demanding processes of skin renewal — keratinocyte turnover requires ~50 atp molecules per cell division, and uv-stressed cells require enhanced atp for nucleotide excision repair of cpd lesions.
How It Works: Inosinate (imp) and guanylate (gmp) enter the purine salvage pathway → amp/gtp → atp via adenylate kinase and gtp synthetase. the energy-dense phosphate anhydride bonds of atp support: collagen synthesis atp-consuming reactions; proteasome atp-dependent protein quality control; dna repair atp-requiring nucleotide excision repair enzymes.
Typically Found In: Energy skin care,uv repair support,anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Purine nucleotides are gras food additives (umami flavour enhancers, e627/e631) with extensive food safety documentation — the same safety profile supporting cosmetic use at equivalent concentrations.
Last Verified: 2026-03-22
Primary Sources: Cosing database,disodium inosinate purine nucleotide energy skin care review