Common Name(s): Eugenyl glucoside,eugenyl glucoside,eugenol glycoside,stabilised phenylpropanoid

CAS Number: N/a

DESCRIPTION

What It Does: Provides glucosidase-released eugenol for antioxidant, antimicrobial, and anti-inflammatory activity with the glucoside form significantly reducing eugenol's direct skin sensitisation risk compared to free eugenol.

Why It's Used: Eugenyl glucoside is selected as the safe eugenol delivery format — the glucoside masking of the reactive phenol group eliminates the oxidative haptenation pathway responsible for eugenol sensitisation, while the skin glucosidase hydrolysis provides controlled-release eugenol activity.

How It Works: Eugenyl glucoside → skin beta-glucosidase hydrolysis → eugenol release → phenolate radical scavenging + cox-2 inhibition + antimicrobial cell membrane disruption; glucoside: masked phenol → reduced sensitisation vs free eugenol.

Typically Found In: Anti-inflammatory,antioxidant

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Eugenol is ifra-restricted in many fragrance applications due to sensitisation potential — eugenyl glucoside provides a registered alternative that delivers eugenol pharmacology within safe skin contact guidelines.

Last Verified: 2026-03-22

Primary Sources: Cosing database,eugenyl glucoside stabilised eugenol glycoside review