Common Name(s): Ficus extract protease,fig protease

CAS Number: 9001-33-6

DESCRIPTION

What It Does: Provides enzymatic exfoliation across a broader ph range than papain, including in cleansing formulations.

Why It's Used: Broader-ph enzyme alternative to papain for cleansers and formulations operating above papain's optimal ph range.

How It Works: Cysteine protease active from ph 5-8 (broader than papain's 5.5-7 range). digests keratin proteins for enzymatic exfoliation. similar substrate specificity to papain with comparable exfoliation efficacy.

Typically Found In: Enzyme cleansers,gentle exfoliants

TECHNICAL DETAILS

Primary Category: Active ingredient – enzyme

Secondary Functions: Broad-ph enzymatic exfoliation

Application Areas:

Typical Concentration Range: 1%–5%

SOURCING & ETHICS

Vegan Status: Yes – from ficus carica latex

Halal Status: Yes

Source Notes: Plant-derived (papaya, pineapple) or fermentation-derived.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Patch test recommended; potential for enzymatic sensitization.

Safe for Sensitive Skin: Use with caution – potential sensitization

SAFETY & COMPATIBILITY

Safety Profile: Safe at cosmetic concentrations. patch test recommended. ewg score: 1–2.

Works Well With: Ahas (synergistic),hyaluronic acid,ceramides

Avoid Combining With: High concentrations on sensitive or compromised skin

SCIENTIFIC NOTE

Ficin's activity at ph 7-8 (papain loses activity above ph 7) makes it the preferred enzyme for cleansing formulations operated at skin-neutral or slightly alkaline ph, where papain would be inactive.

Last Verified: 2026-03-12

Primary Sources: Cosing database,cir safety assessment