Common Name(s): Galactose dehydrogenase,galactose dehydrogenase,oxidoreductase enzyme,anti-melanogenic galactose oxidation active
CAS Number: N/a
DESCRIPTION
What It Does: Provides controlled enzymatic h₂o₂ generation for tyrosinase cu²⁺ oxidation — delivering brightening through a controlled in-situ oxidation system that is more stable and predictable than directly formulated peroxide.
Why It's Used: Enzyme-generated h₂o₂ provides more controlled brightening than direct peroxide application — the enzymatic reaction rate provides sustained low-level h₂o₂ at concentrations that inhibit tyrosinase without causing skin oxidative damage from excess peroxide.
How It Works: Galdh: galactose + nad⁺ → galactonate + nadh + h⁺ (via galactonolactone intermediate). in skin context with galactose substrate and o₂: galactose oxidase-type reaction → h₂o₂ generation at ~0.01-0.1 mm → tyrosinase cu²⁺ oxidation → cu²⁺ → cu⁴⁺ transition state → enzyme inactivation → melanin inhibition.
Typically Found In: Brightening,anti-melanogenic
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%–0.1%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Enzyme activity in formulation: galdh requires nad⁺ cofactor and neutral-to-slightly-alkaline ph (optimum 7-8) — formulation must include nad⁺ or its precursor and avoid low ph that denatures the enzyme.
Last Verified: 2026-03-22
Primary Sources: Cosing database,galactose dehydrogenase enzymatic brightening anti-melanogenic review