Common Name(s): D-glucono-delta-lactone,gdl,gluconic acid lactone
CAS Number: 90-80-2
DESCRIPTION
What It Does: Provides gentle pha exfoliation with antioxidant chelation and preservative system enhancement.
Why It's Used: The multifunctional pha โ gluconolactone provides pha exfoliation alongside antioxidant chelation and preservative system boosting in a single sensitive-skin-compatible ingredient.
How It Works: Hydrolyses to gluconic acid (pha) in aqueous formulation. 5 hydroxyl groups provide humectant water binding. gluconate chelates iron and copper for antioxidant via fenton inhibition. preservative enhancement from chelation disrupting gram-negative bacterial outer membrane. very gentle exfoliation from large pha molecular size.
Typically Found In: Gentle pha exfoliants,sensitive skin toners,preservative enhancement systems
TECHNICAL DETAILS
Primary Category: Active ingredient โ polyhydroxy acid (pha)
Secondary Functions: Gentle exfoliation,antioxidant,humectant
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 2%โ15%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Fermentation-derived from sugars or synthetic. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: No photosensitization; no stinging; suitable for very sensitive skin.
Safe for Sensitive Skin: Yes โ ideal for sensitive, reactive, rosacea, eczema-prone skin
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. no photosensitization. ewg score: 1.
Works Well With: Ceramides,niacinamide,hyaluronic acid,soothing actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Gluconolactone's preservative boosting via iron/calcium chelation demonstrates the same mechanism as edta: chelating divalent cations that stabilise gram-negative bacterial outer membranes destabilises the membrane barrier, making gram-negative bacteria vulnerable to preservatives that cannot otherwise penetrate the intact outer membrane.
Last Verified: 2026-03-12
Primary Sources: Cosing database,green & yu pha review,cir safety assessment