Common Name(s): Lamiblast,hexapeptide-10

CAS Number: N/a

DESCRIPTION

What It Does: Stimulates laminin-5 synthesis to strengthen the dermoepidermal junction and improve skin firmness.

Why It's Used: Targets the often-overlooked dermoepidermal junction (dej) aging – structural weakening of the dej is a primary cause of age-related skin sagging.

How It Works: Laminin-5 (also called laminin-332) is the primary anchoring protein at the dej attaching the epidermis to dermis. hexapeptide-10 upregulates laminin-5 synthesis in keratinocytes, strengthening this junction for improved firmness.

Typically Found In: Anti-aging serums,skin firming products

TECHNICAL DETAILS

Primary Category: Active ingredient – laminin-stimulating peptide

Secondary Functions: Dej strengthening,skin firmness,laminin stimulation

Application Areas:

Typical Concentration Range: 50–500 ppm

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes

Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

The dermo-epidermal junction (dej) weakens progressively with aging, contributing to skin sagging more significantly than collagen loss alone. strengthening dej anchoring proteins (laminins, type iv collagen, integrins) represents an underutilized anti-aging target that hexapeptide-10 uniquely addresses.

Last Verified: 2026-03-12

Primary Sources: Cosing database,dej anti-aging research,gorouhi & maibach peptide review