Common Name(s): Hoodia gordonii extract,hoodia gordonii extract,steroidal glycoside appetite suppressant,p57 adenosine-mimetic active
CAS Number: N/a
DESCRIPTION
What It Does: Provides adenosine receptor agonism for skin anti-inflammatory activity from the p57 oxypregnane glycoside's adenosine-mimetic pharmacology, alongside steroidal backbone skin conditioning.
Why It's Used: Hoodia p57's adenosine receptor mechanism is the same anti-inflammatory pathway activated by adenosine — a2a receptor-mediated camp → pka → anti-inflammatory gene expression provides cosmetically applicable anti-inflammatory activity from the traditional bushman plant.
How It Works: P57 oxypregnane glycoside: the steroid backbone with oxygen substituents mimics adenosine's topology for a2a receptor binding → gs-camp-pka cascade → nf-kb inhibition → reduced tnf-α/il-1β production → anti-inflammatory activity. the traditional hunger-suppressant mechanism adapts to topical anti-inflammatory skin care.
Typically Found In: Anti-inflammatory,sensitive skin
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Hoodia gordonii is cites appendix ii protected — certified sustainable cultivation from south african farms or cites-compliant wild harvest documentation required for regulatory compliance in cosmetic ingredient sourcing.
Last Verified: 2026-03-22
Primary Sources: Cosing database,hoodia gordonii p57 adenosine anti-inflammatory review