Common Name(s): Human fibroblast extra cellular matrix powder,human fibroblast extra cellular matrix powder,human fibroblast conditioned media,growth factor cytokine complex
CAS Number: N/a
DESCRIPTION
What It Does: Delivers the complete cellular signalling cocktail secreted by human fibroblast cells — growth factors, cytokines, extracellular vesicles (exosomes), and matrix proteins that activate skin cell renewal, collagen synthesis, and barrier repair through simultaneous multi-receptor pathway engagement.
Why It's Used: Conditioned media provides the complete paracrine signalling environment that isolated growth factor supplements cannot replicate — the synergistic combination of 50–100+ bioactive molecules activating concurrent receptor pathways provides anti-aging responses beyond any single factor.
How It Works: Conditioned media collection: cells grown to confluence → serum-free culture → 24–72h conditioning → filtered secretome. egf → egfr/erk → keratinocyte renewal; fgf-2 → fgfr/pi3k → fibroblast collagen synthesis; tgf-β → smad2/3 → elastin; vegf → improved vascularity; exosomes (50–150 nm evs) deliver mirna cargo altering gene expression in recipient skin cells.
Typically Found In: Premium anti-aging,regenerative skin care,stem cell technology
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–5%
SOURCING & ETHICS
Vegan Status: No - human-derived
Halal Status: No - human-derived; majority prohibition (juz' al-adami) - panel confirmation required
Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: name declares human tissue, fluid or cell culture. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Conditioned media regulatory status: varies by origin — human-derived conditioned media may trigger cosmetic ingredient classification review in some markets. pantoea vagans bacterial conditioned media (targeting specific cell types) may face novel ingredient classification. verify each specific ingredient's regulatory status in target markets.
Last Verified: 2026-03-22
Primary Sources: Cosing database,human fibroblast extra cellular mat conditioned media growth factor review