Common Name(s): Isodon inflexus extract,isodon inflexus extract,chalcone phytochemical,anti-inflammatory antioxidant

CAS Number: N/a

DESCRIPTION

What It Does: Provides potent nf-kb anti-inflammatory activity through covalent ikk-β inhibition from the michael acceptor chalcone/diterpenoid carbonyl — sustained anti-inflammatory duration exceeding the tissue half-life from the irreversible inhibition mechanism.

Why It's Used: Chalcone and labdane diterpenoids provide covalent nf-kb inhibition — the alpha,beta-unsaturated carbonyl's irreversible bond to cys179 provides hours of anti-inflammatory activity from a brief skin contact.

How It Works: Alpha,beta-unsaturated carbonyl michael acceptor → ikk-β cys179 adduct (permanent) → nf-κb blockade → tnf-α/il-1β/il-6 reduction. catechol groups additionally provide radical scavenging for antioxidant activity.

Typically Found In: Anti-inflammatory,anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Covalent inhibitor duration: the cys179 adduct persists until new ikk-β protein is synthesised (half-life ~4-6 hours) — providing anti-inflammatory activity well beyond the ingredient's 1-2 hour skin residence time.

Last Verified: 2026-03-22

Primary Sources: Cosing database,isodon inflexus extract chalcone labdane anti-inflammatory review