Common Name(s): Isoniacinamide,isoniacinamide,niacin derivative,vasodilating circulation-stimulating active
CAS Number: N/a
DESCRIPTION
What It Does: Provides niacinamide-equivalent melanin transfer inhibition for brightening from the nicotinamide ring pharmacology, with improved sc penetration from the ester or structural modification.
Why It's Used: Niacin derivatives separate the beneficial skin circulation or brightening activity from the limiting characteristics of the parent compound — improving delivery or reducing irritation while retaining the core pharmacological mechanism.
How It Works: Nicotinate ester: skin esterases → nicotinic acid → gpr109a receptor on langerhans cells → pgd2 → dp1 receptor → vasodilation. niacinamide-type: nicotinamide ring competition with parp substrate reducing adenosine diphosphoribose transfer in melanocyte-keratinocyte junction.
Typically Found In: Brightening,anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–2%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Onset delay from ester hydrolysis: isopropyl ester hydrolysis provides delayed-onset vasodilation more comfortable than direct nicotinic acid application — patient preference for the gradual warming onset supports formulation adoption.
Last Verified: 2026-03-22
Primary Sources: Cosing database,isoniacinamide niacin derivative vasodilation review