Common Name(s): Lactobacillus ferment lysate filtrate,lactobacillus ferment lysate filtrate,lactobacillus lab postbiotic,acid mantle anti-acne active

CAS Number: N/a

DESCRIPTION

What It Does: Reinforces skin acid mantle through lactic acid production, provides selective c. acnes/s. aureus antimicrobial protection from bacteriocins, and delivers tlr2-mediated anti-inflammatory trained immunity.

Why It's Used: Lactobacillus postbiotics are the most clinically validated cosmetic microbiome actives — acid mantle reinforcement, bacteriocin selectivity, and tlr2 immunomodulation are each independently documented in dermatology literature.

How It Works: Lab fermentation: lactic acid (ph 4.5-5.0 reinforcement); class iia bacteriocins (selective gram-positive pathogen pore formation); lta (tlr2/tlr6 → il-10 anti-inflammatory tolerance); beta-glucosidase (polyphenol glycoside → aglycone, 10-50× sc penetration improvement).

Typically Found In: Microbiome skin care,anti-acne,postbiotic

TECHNICAL DETAILS

Primary Category: Active ingredient – skin microbiome support

Secondary Functions: Microbiome balance,prebiotic effect

Application Areas:

Typical Concentration Range: 0.5%–15%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Fermentation-derived or plant-extracted.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; beneficial for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,niacinamide,soothing actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Substrate selection is the primary formulation lever — the organism's core lab metabolite profile is constant, but substrate chemistry determines the supplementary bioactive portfolio for targeted skin care claims.

Last Verified: 2026-03-22

Primary Sources: Cosing database,lactobacillus postbiotic lab microbiome review