Common Name(s): Lupeol,lupeol,pentacyclic triterpene,anti-inflammatory 5-ar inhibitor anti-aging
CAS Number: N/a
DESCRIPTION
What It Does: Inhibits 5-alpha-reductase for sebum overproduction control, provides nf-kb anti-inflammatory activity, delivers anti-melanogenic brightening, and antioxidant protection — the pentacyclic triterpene scaffold providing four independent anti-aging and anti-acne mechanisms.
Why It's Used: Lupeol's multi-mechanism activity from one triterpene scaffold provides formulation efficiency — 5-ar inhibition for acne/oiliness combined with nf-kb anti-inflammation and melanogenesis inhibition addressing concurrent acne, sensitivity, and brightening concerns.
How It Works: Lupeol lupane ring: 5α-reductase type i inhibition (ic50 ~5 μm) competing with testosterone → reduced dht → decreased sebaceous lipogenesis. nf-κb: iκb kinase β inhibition → tnf-α/il-1β suppression. melanogenesis: mitf downregulation → tyrosinase/trp-1/trp-2 reduction → brightening.
Typically Found In: Anti-acne,anti-inflammatory,brightening,anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Lupeol distribution: found in mango skin, olives, soybeans, figs, and many medicinal plants — the widespread natural occurrence provides clean beauty narrative alongside the documented multi-mechanism pharmacology.
Last Verified: 2026-03-22
Primary Sources: Cosing database,lupeol lupane triterpene 5-ar nf-kb anti-inflammatory review