Common Name(s): Manganese d-gluconate,manganese supplement
CAS Number: 6485-39-8
DESCRIPTION
What It Does: Provides manganese for mn-sod enzyme support and collagen synthesis cofactor activity.
Why It's Used: Antioxidant enzyme mineral โ manganese's role as the essential metal in mitochondrial manganese superoxide dismutase (mn-sod) provides antioxidant enzyme support from mineral supplementation.
How It Works: Mnยฒโบ is essential catalytic metal in mn-sod (mitochondrial superoxide dismutase) โ the primary mitochondrial antioxidant enzyme. manganese also cofactor for prolidase (proline peptidase for collagen precursor recycling) and galactosyltransferase (proteoglycan synthesis). collagen synthesis cofactor via manganese-dependent post-translational glycosylation.
Typically Found In: Anti-aging mineral products,antioxidant formulas
TECHNICAL DETAILS
Primary Category: Active ingredient โ manganese mineral
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ0.5%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Mn-sod's mitochondrial location makes manganese the specific antioxidant metal for mitochondrial oxidative stress โ the primary source of age-related cellular ros accumulation. by supporting mn-sod activity, manganese supplementation addresses oxidative stress at its mitochondrial origin, complementing cytosolic antioxidants (cu/zn-sod, catalase) that address extra-mitochondrial ros.
Last Verified: 2026-03-12
Primary Sources: Cosing database,cir safety assessment