Common Name(s): Manganese tripeptide-1,manganese tripeptide-1,mn-ghk analogue,manganese-chelated wound healing peptide

CAS Number: N/a

DESCRIPTION

What It Does: Activates mn-sod mitochondrial antioxidant enzyme through bioavailable mn²⁺ delivery, simultaneously stimulates collagen synthesis from ghk tripeptide integrin receptor binding, and promotes wound healing from the combined ghk + manganese receptor pharmacology.

Why It's Used: Mn-ghk provides complementary anti-aging mechanisms to cu-ghk — while copper activates cu/zn-sod (cytoplasmic) and lysyl oxidase (extracellular collagen crosslinking), manganese activates mn-sod (mitochondrial) for intracellular reactive oxygen species management.

How It Works: Mn²⁺ chelation by his-imidazole + lys-amino groups → controlled mn²⁺ release in mitochondria → mn-sod (tetrameric, each monomer binds one mn²⁺) → o₂•⁻ → h₂o₂ + o₂ dismutation → reduced mitochondrial oxidative stress. ghk → integrin α2β1 → fak → col1a1/col3a1 upregulation.

Typically Found In: Premium anti-aging,mitochondrial support

TECHNICAL DETAILS

Primary Category: Active ingredient – peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Typical Concentration Range: 1–5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Mn-sod vs cu/zn-sod compartmentalisation: mn-sod operates in the mitochondrial matrix targeting the primary site of cellular ros generation (etc leakage), while cu/zn-sod operates in the cytoplasm and intermembrane space — the two sod systems provide complementary intracellular compartment protection.

Last Verified: 2026-03-22

Primary Sources: Cosing database,manganese tripeptide-1 mn-ghk sod anti-aging review