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Common Name(s): Mangostin,mangostin (alpha-mangostin),garcinia xanthone,potent anti-inflammatory antioxidant

CAS Number: N/a

DESCRIPTION

What It Does: Provides potent xanthone antioxidant protection (dpph ic50 ~5 ฮผm), dual nf-kb/cox-2 anti-inflammatory coverage, antimicrobial activity against c. acnes for anti-acne applications, and mild tyrosinase inhibitory brightening.

Why It's Used: Mangostin's xanthone scaffold provides the highest antioxidant activity per mole of any known tricyclic aromatic natural compound โ€” the fully conjugated 9h-xanthen-9-one ring system providing multiple sequential radical donation from four hydroxyl groups.

How It Works: Alpha-mangostin (1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9h-xanthen-9-one): the xanthone ring provides four adjacent oh groups for radical donation (dpph ic50 ~5 ฮผm). nf-ฮบb: iฮบb kinase inhibition via xanthone ap-1 kinase interaction. cox-2: xanthone active site competitive binding (ic50 ~8 ฮผm). c. acnes: membrane disruption from xanthone amphiphilicity.

Typically Found In: Anti-inflammatory,anti-acne,antioxidant,brightening

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%โ€“1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Mangosteen pericarp concentration: alpha-mangostin constitutes 1-3% of dried mangosteen pericarp โ€” thailand, indonesia, and malaysia provide the primary supply. standardised extracts to >10% xanthones provide consistent bioactivity for clinical claim support.

Last Verified: 2026-03-22

Primary Sources: Cosing database,alpha-mangostin garcinia xanthone anti-inflammatory antioxidant review