Common Name(s): D-mannose,carubinose
CAS Number: 3458-28-4
DESCRIPTION
What It Does: Provides humectant hydration with unique wound healing activity via macrophage mannose receptor stimulation.
Why It's Used: Functional sugar humectant with wound healing activity beyond simple moisture binding โ particularly relevant in post-procedure and repair formulations.
How It Works: Binds mannose receptor (mr/cd206) on macrophages and dermal fibroblasts stimulating wound healing growth factor release and collagen synthesis. multiple hydroxyl groups provide humectant activity comparable to glucose.
Typically Found In: Wound healing products,post-procedure recovery,anti-aging serums
TECHNICAL DETAILS
Primary Category: Active ingredient โ epimer sugar humectant
Secondary Functions: Mannose receptor activation,wound healing,humectant
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ5%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Synthetic or naturally derived. excellent aqueous solubility. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
The macrophage mannose receptor (cd206) is a pattern recognition receptor that recognizes high-mannose glycan patterns on pathogens and endogenous mannose-terminated glycoproteins. d-mannose topical application activates this receptor on dermal fibroblasts and macrophages, stimulating tgf-beta and growth factor release that promotes collagen synthesis and wound healing.
Last Verified: 2026-03-12
Primary Sources: Cosing database,medina-torres et al. mannose wound healing review