Common Name(s): Matrixyl 3000 component,rigin,palmitoyl gqpr

CAS Number: 272459-84-6

DESCRIPTION

What It Does: Provides il-6-targeting anti-inflammaging activity as matrixyl 3000's immunomodulating component.

Why It's Used: Inflammaging-targeting peptide — palmitoyl tetrapeptide-7 targets the il-6-driven chronic skin inflammation (inflammaging) that accelerates collagen degradation in aging skin, providing anti-aging from a unique anti-inflammatory mechanism.

How It Works: Gqpr sequence mimics tuftsin (natural immunomodulating tetrapeptide). inhibits il-6 overproduction in aged fibroblasts and keratinocytes reducing chronic low-grade inflammatory mmp activation. stimulates ecm protein synthesis including collagen and fibronectin. used with palmitoyl oligopeptide as matrixyl 3000.

Typically Found In: Premium anti-aging serums,matrixyl 3000 products

TECHNICAL DETAILS

Primary Category: Active ingredient – signal peptide

Secondary Functions: Collagen stimulation,skin firming,anti-aging

Application Areas:

Typical Concentration Range: 0.0001%–0.01%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

Matrixyl 3000's two-peptide combination (palmitoyl oligopeptide + palmitoyl tetrapeptide-7) targets aging from two complementary directions: palmitoyl oligopeptide stimulates collagen synthesis (anabolic anti-aging), while palmitoyl tetrapeptide-7 inhibits inflammaging-driven il-6 collagen destruction (catabolic anti-aging). together they provide a comprehensive two-pronged anti-aging approach.

Last Verified: 2026-03-12

Primary Sources: Cosing database,sederma matrixyl 3000 technical data