Common Name(s): Mk-7,vitamin k2 mk-7

CAS Number: 2124-57-4

DESCRIPTION

What It Does: Activates mgp to prevent soft tissue calcification and improve skin elasticity and structural integrity.

Why It's Used: Premium anti-aging for preventing cutaneous calcification and maintaining elastin integrity via mgp activation.

How It Works: As cofactor for vitamin k-dependent carboxylase, mk-7 activates mgp through gamma-carboxylation. active mgp inhibits calcium crystal deposition in elastin fibers maintaining flexibility.

Typically Found In: Premium anti-aging products,skin elasticity formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – vitamin k2 (mk-7)

Secondary Functions: Anti-calcification,elastin protection

Application Areas:

Typical Concentration Range: 0.01%–0.5%

SOURCING & ETHICS

Vegan Status: Yes – bacterial fermentation (bacillus subtilis natto)

Halal Status: Yes

Source Notes: Produced by bacillus subtilis natto fermentation. mk-7 has the longest biological half-life of all menaquinone forms.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating at cosmetic concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1. caution for patients on warfarin.

Works Well With: Retinol,caffeine,peptides,ceramides

Avoid Combining With: Warfarin anticoagulant therapy (consult physician)

SCIENTIFIC NOTE

Vitamin k-dependent mgp activation prevents soft tissue calcification. calcification of elastin fibers is a hallmark of photoaging. topical mk-7 may preserve elastin flexibility by maintaining mgp activation in dermal fibroblasts.

Last Verified: 2026-03-12

Primary Sources: Cosing database,maresz mgp review,schurgers et al. vitamin k2 studies