Common Name(s): Menthone glycerin acetal,menthone glycerin acetal,menthol equivalent cooling active,sustained trpm8 stimulator
CAS Number: N/a
DESCRIPTION
What It Does: Provides trpm8-mediated cooling sensation equivalent to menthol without menthol's oxidative instability and overpowering peppermint fragrance โ enabling cooling sensory effects in formulations where menthol's scent intensity or stability would be problematic.
Why It's Used: Menthone glycerin acetal separates menthol's cooling function from its overpowering peppermint fragrance โ the acetal form provides pure trpm8 cooling with minimal aromatic character for cooling products where menthol scent is undesirable.
How It Works: The cyclic 1,3-dioxane acetal ring of menthone glycerin acetal activates trpm8 (cold/menthol receptor) at the same binding domain as l-menthol โ the acetal oxygen geometry mimics the menthol hydroxyl's trpm8 active site interaction. the ring's hydrolytic stability versus menthol's aldehyde oxidation provides 5-10ร improved formulation shelf stability.
Typically Found In: Cooling products,after-sun,deodorants
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Trpm8 cooling potency: menthone glycerin acetal ec50 for trpm8 activation ~50 ฮผm vs menthol ec50 ~10 ฮผm โ slightly less potent than menthol but the improved stability and reduced fragrance load make it preferred at equivalent functional concentrations.
Last Verified: 2026-03-22
Primary Sources: Cosing database,menthone glycerin acetal trpm8 cooling menthol alternative review