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Common Name(s): Methionyl sh-polypeptide-10,methionyl sh-polypeptide-10,methionyl-extended signal peptide complex,multi-receptor anti-aging bioactive

CAS Number: N/a

DESCRIPTION

What It Does: Provides multi-receptor-targeted collagen synthesis stimulation from the complex peptide sequence with methionyl protection against aminopeptidase degradation โ€” extending in-skin half-life for sustained anti-aging activity.

Why It's Used: Methionyl extension is a stabilisation strategy โ€” the n-terminal methionine protects against aminopeptidase a cleavage of the underlying peptide sequence, providing 3-5ร— extended half-life without altering the core pharmacophore receptor binding.

How It Works: Met-extension: methionine aminopeptidase has poor affinity for n-terminal met before bulky or charged p1 residues โ€” selective protection of the active peptide sequence. core sequence โ†’ tgf-ฮฒ/integrin receptor binding โ†’ smad2/3 โ†’ col1a1/eln upregulation. multiple peptide components target complementary receptors for synergistic anti-aging.

Typically Found In: Premium anti-aging,collagen products

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1โ€“5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Methionyl extension in natural proteins: met-extensions are found in nascent polypeptides before ribosomal methionine aminopeptidase processing โ€” this natural stabilisation mechanism adapted for cosmetic peptide half-life extension.

Last Verified: 2026-03-22

Primary Sources: Cosing database,methionyl sh-polypeptide-10 methionyl peptide complex review