Common Name(s): Methionyl sh-polypeptide-7 alanyl sr-spider oligopeptide-1

DESCRIPTION

What It Does: Combines fgf analog skin renewal with spider silk-inspired mechanical strengthening.

Why It's Used: Used for anti-aging with added skin mechanical resilience from spider silk peptide.

How It Works: Sh-polypeptide-7 (fgf-7/kgf analog) activates fgfr2b for keratinocyte proliferation; sr-spider oligopeptide-1 (silk peptide) provides beta-sheet-forming mechanical resilience similar to spider silk.

Typically Found In: Premium anti-aging serums,biomimetic skin care

TECHNICAL DETAILS

Primary Category: Active ingredient – peptide

Secondary Functions: Anti-aging active,skin conditioning agent

Application Areas:

Typical Concentration Range: 0.001%–0.1%

SOURCING & ETHICS

Vegan Status: Conditional - recombinant or synthetic; confirm no animal-derived material in expression or culture system

Halal Status: Unverified - recombinant or synthetic; confirm material origin, not sequence origin

Source Notes: Synthetic peptide complex; spider silk sequence-inspired sr-oligopeptide; methionyl-modified fgf analog. [audit 2026-07-29 rev2: pass-1 miss: animal species token absent from the pass-1 list; recombinant prefix present so routed to material-origin confirmation. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Generally well tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile. ewg score: 1.

Works Well With: Other peptides,niacinamide,retinoids

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Spider silk proteins (spidroin) form extremely strong beta-sheet secondary structures; sr-spider oligopeptide-1 is a recombinant spider silk-inspired peptide providing mechanical resilience benefits to skin.

Last Verified: 2026-03-28

Primary Sources: Cosing database,inci dictionary