Common Name(s): Methoxy peg-200 betulin,methoxy peg-200 betulin,pegylated betulin,water-soluble birch triterpene anti-inflammatory
CAS Number: N/a
DESCRIPTION
What It Does: Provides betulin's anti-inflammatory nf-kb inhibition and skin barrier repair in a water-soluble pegylated form enabling aqueous formulation incorporation โ eliminating the insolubility limitation of native betulin for use in serums and emulsions.
Why It's Used: Betulin pegylation solves the primary formulation barrier to betulin's clinical potential โ native betulin is practically insoluble in water (logp ~7.6), limiting cosmetic use to anhydrous systems; pegylation raises aqueous solubility >1000ร enabling serum and cream incorporation.
How It Works: Betulin lupane triterpene (2ฮฒ,3ฮฒ-diol, lupane skeleton): ikk-ฮฒ inhibition โ nf-ฮบb โ anti-inflammatory; skin barrier: beta-glucocerebrosidase activation โ ceramide synthesis from glucosylceramide โ sc lipid barrier repair. pegylation at the c3 or c28 hydroxyl: methoxy peg chain raises solubility without blocking the 2ฮฒ-hydroxyl pharmacophore for ikk binding.
Typically Found In: Anti-inflammatory,barrier repair,premium actives
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Betulin vs betulinic acid: betulin (28-alcohol) provides superior skin barrier activity; betulinic acid (28-carboxylic acid) provides stronger anti-proliferative activity. pegylated betulin targets the barrier-repair and anti-inflammatory applications specifically.
Last Verified: 2026-03-22
Primary Sources: Cosing database,methoxy peg-200 betulin pegylated betulin anti-inflammatory review